Real Science with Real Scientists

Omar Zaid
Omar Zaid

In this interview, return guest Stephanie Seneff, Ph.D., a senior research scientist at MIT who has been at MIT for over five decades, discusses her latest paper, "Innate Immune Suppression by SARS-CoV-2 mRNA Vaccinations. The Role of G-quadruplexes, Exosomes and MicroRNAs," co-written with Dr. Peter McCullough, along with two other authors, Dr. Greg Nigh and Dr. Anthony Kyriakopoulos.

Previously, Nigh and Seneff co-wrote an entire paper detailing the differences between the spike protein and the COVID jab spike protein. In a non-peer-reviewed research paper just this week published on the pre-print service authorea, they and their other co-authors delve deeply into the mechanisms of the COVID shots, showing how they absolutely, in no way, shape or form, are safe or effective. The shots actually suppress your innate immune system.

Pharma has so much money behind [them] and they've got it all set up to make sure that nothing gets past them ...

On January 16, 2022, the pre-print service Authorea published this paper on its web site, assigning it a DOI, thus making it official.

Exceptionally Strong Safety Signals

As noted by Seneff, when you look at the various databases for adverse effects, you can see an exceptionally strong safety signal — and the COVID shot developers know that. "The numbers are out of sight," Seneff says, and this goes for all levels of side effects, from mild to catastrophic.

Seneff has been looking at the cancer data, for example, and on average, there are twice as many reports of cancer following the COVID shots compared to all other vaccines combined over the last 31 years.

The fact that the signal is that strong is even more remarkable when you consider that most people don't think the COVID shot could be a variable in their cancer emergence, so they never report it. "It puzzles me that they're willing to do such damage to the health of the whole population of the world. I don't understand that degree of evilness," Seneff says.

vaers stats cancer seneff study covid

© Stephanie Seneff, Greg Nigh, Anthony M. Kyriakopoulos, Peter A McCullough
Vaers reports table from Dr. Stephanie Seneff' paper studying the covid vaccine's effect on the immune systemType-1 Interferon Disruption

The shots suppress your innate immune system by inhibiting type-1 interferon. One of the first studies to tip off Seneff and McCullough to this was an Indian study, in which human cells grown in a culture were exposed to the DNA nanoparticles that instruct them to make SARS-CoV-2 spike protein, much like the COVID shots do.1

The cell strain is called HEK-293. These are cells that were taken from the kidneys of an aborted fetus in the 1980s and are frequently used in research. While taken from the kidneys, these cells have neuron-like properties. When programmed to make spike protein, these cells release that spike protein inside exosomes — lipid nanoparticles inside which the spike protein is packaged.

Exosomes act as a communication network for cells. When a cell is under stress, it releases exosomes containing some of the molecules that are stressing it. So, in the case of the COVID shots, the exosomes contain spike protein and microRNA. MicroRNAs are signaling molecules that are able to influence cell function. They cause the cell to change its behavior or metabolism. Typically, they do this by suppressing certain enzymes.

The Indian study found two specific microRNAs inside the exosomes released by these neuron-like cells: miR-148a and miR-590. The researchers then exposed microglia (immune cells in your brain) to these exosomes. So, as explained by Seneff, you've got neurons in your brain producing spike protein, or taking up spike protein that is in circulation, and reacting to it by releasing exosomes.

The exosomes are then picked up by microglia, the immune cells in your brain. When the immune cells receive those exosomes, they turn on an inflammatory response. This is primarily a response to those microRNAs, the miR-148a and miR-590. Of course, you also have the toxic spike protein there.

Combined, they cause inflammation in the brain, which damages neurons. This inflammation, in turn, can contribute to a number of degenerative brain disorders. The lipid particles in the COVID shot, which contain the mRNA, are similar to exosomes, but not identical. They're also very similar to low-density lipid (LDL) particles.

But then they throw in this cationic lipid, which is really, really toxic — a synthetic cationic lipid that makes it positively charged. Experimentally, they've found that this lipid, when the particle is taken up by the cell, is released into the cytoplasm, [where] that mRNA then makes spike protein.

Seneff wrote an entire paper2 detailing the differences between the viral spike protein and the COVID jab spike protein, together with Greg Nigh, which was published in the International Journal of Vaccine Theory, Practice and Research in May 2021. It basically serves as a primer for understanding what we discuss here.

Getting back to the Indian paper cited above, they found that the microglia ended up producing inflammation in the brain, and the two microRNAs were central in this process. The miR-148a and miR-590 were put into those exosomes with the spike protein, and these two microRNAs are able to significantly disrupt the type-1 interferon response in any cell, including immune cells.

Type-1 interferon also keeps latent viruses like herpes and varicella (which causes shingles) viruses in check, so if your interferon pathway is suppressed, these latent viruses can also start to emerge. The VAERS database reveals many who have been jabbed do report these kinds of infections. Suppressed interferon also raises your risk of cancer and cardiovascular disease.

Type-1 Interferon Response Is Crucial in Viral Infections

As explained by Seneff, the type-1 interferon response is absolutely crucial as the first-stage response to a viral infection. When a cell is invaded by a virus, it releases type-1 interferon alpha and type-1 interferon beta. They act as signaling molecules that tell the cell that it's been infected.

That, in turn, launches the immune response and gets it going early in the viral infection. It's been shown that people who end up with severe SARS-CoV-2 infection have a compromised type-1 interferon response. As noted by Seneff:

Importantly, the antibody response you get from the COVID shot is exponentially higher than what you get from natural infection, and research has shown that the level of antibody response rises with disease severity. So, the shot basically mimics severe infection. In mild infection, you may not produce any antibodies at all, because the innate immune cells are strong enough to fight off the infection without them.

It's when your innate immune system is weak that you get into trouble, and part of that weakness is a suppressed type-1 interferon response. If your type-1 interferon response is deficient, your immune cells are not very capable of stopping the spread of the virus in your body.

According to Seneff, the reason type-1 interferon supplementation has not been recommended thus far is because you have to time it perfectly in order for the immune cascade to function properly. Type-1 interferon plays a definitive role only at the very earliest stage of the infection. Once you've entered a moderate or severe infection stage, it's too late to use it.

COVID Shots Confuse Your Immune System

As noted by Seneff, the COVID shots are so unnatural that your immune system doesn't quite know what to do anymore.

It's as if the human immune cells suddenly decided to make a really toxic protein, and make lots of it — which is exactly what they're doing — and the immune system is completely baffled by this. The immune cells have no clue what to do with it.

There are also antibodies that enhance disease rather than fight it, and the level of these antibodies declines at a slower pace than the protective antibodies. So, after a number of months you end up with a NEGATIVE immune response. In other words, you're now more prone to infection than ever before. As explained by Seneff:

"There's a crossover point at which the enhancing antibodies can be stronger than the protective antibodies, and that's when you can get this antibody dependent enhancement (ADE) that people have seen in the past with [other] coronavirus vaccines. We're still trying to see if that's the case with [the COVID jabs]. There is some evidence here and there, but it's not [conclusive yet]."

The Importance of Cytotoxic T-Cells

After the India study tipped off Seneff and McCullough to the interferon problem, they came across a Chinese study3 that tracked the effect of the COVID jab on the immune system over time. Here, they discovered that the infection caused an increase in CD8+ T-cells, important cytotoxic T-cells that actually remove infected cells.

As noted by Seneff, the CD8+ cells are an important part of the defense against SARS-CoV-2. Importantly, CD8+ T-cells were enhanced in response to natural infection, but not in response to the COVID shot. They too found type-1 interferon suppression post-jab. So, in the aftermath of the jab, not only is your first-line response depressed — the type-1 interferon response — but you're also missing the part of the immune response that cleans away infected cells.

The microRNA That Influences Myocarditis Risk

A third microRNA (mRNA) created by natural SARS-CoV-2 infection is miR-155, and it plays an important role in heart health. Early on in the pandemic, there were reports of COVID-19 causing heart problems.

Seneff suspects the miR-155-containing exosomes may also be present post-jab, and may play a role in the heart damage that's being reported. Specifically, miR-155 is associated with myocarditis. As mentioned earlier, microRNA suppresses certain proteins that then cause a complicated cascade response. When a particular protein that is a critical player gets suppressed by a microRNA, then a whole different cascade takes place.

Why Autoimmune Problems May Arise Post-Jab

The antibodies produced by the jab also have several short peptide sequences in them that have previously been found in several human cells that are related to autoimmune disease. Seneff explains:

you build a really strong antibody response to the spike protein, those antibodies can get confused and they can attack a human protein that has a similar sequence.

That's a classic form of autoimmune disease. It's called molecular mimicry. There were many different proteins that matched. It was quite surprising ... It seems to be very well designed to induce autoimmune disease, if you produce antibodies to those sequences in the spike protein."

Neurological Problems in Women

The shots are also tightly associated with neurological problems such as uncontrollable tremors and shaking. Curiously, this side effect disproportionally affects women. The mechanism here again involves the exosomes. Seneff explains:

When you look at the VAERS database, you see tremendous signals for all kinds of things that suggest different nerves are being inflamed.

Tinnitus is going to be inflammation of the auditory nerve.

Bell's palsy, which is inflammation of the facial nerve.  8,000 cases of migraine headache, which is linked to an inflammation of the trigeminal nerve.

It probably also goes, I suspect, along the nerve fibers of the spinal column, which may be causing some of these cases where they're finding paralysis.

Sulfatide, an important lipid carrier, is the only sulfonated lipid in the human body. Your liver makes most of the sulfatide, which is then carried by your platelets (blood cells) to other areas in your body. The myelin sheath contains high amounts of sulfatide. It's part of what protects the myelin sheath. In demyelinating diseases, that sulfatide erodes, ultimately allowing the myelin to be attacked.4

Seneff believes the COVID jab results in significant myelin damage, thanks to these inflammatory exosomes. This damage does not necessarily show up right away, although some jab recipients experience acutely devastating effects. It could take 10 years or more before a demyelinating disease sets in.

"I think we're going to see people getting these neurodegenerative diseases earlier and earlier in life than they used to," Seneff says, "and I think anybody who already has any of these diseases is going to have accelerated progression."

We May Soon See an Explosion of Parkinson's Cases

Disturbingly, loss of smell and dysphagia, the inability to swallow, are both signs of Parkinson's disease, and both of these conditions are being reported post-jab by the thousands. So, in years to come, we could be looking at an explosion of Parkinson's.

all of these molecules that are prion-like. There's the prion protein itself, which is associated with CJD, Creutzfeldt-Jakob disease, but then there's the alpha-synuclein and amyloid beta, there's TDP-43, which is associated with ALS.

All of those diseases are overrepresented in the VAERS database for the COVID shots, compared to all the other vaccines combined over 31 years. It's just completely out of line.

Health Problems We Can Expect to See More Of

In time, Seneff predicts we'll see a dramatic increase in infections and cancers of all types, autoimmune diseases, neurodegenerative diseases and reproductive issues. As mentioned, research has demonstrated that the spike protein accumulates in the spleen and women's ovaries.

Without doubt, inflammation in the ovaries is not a good thing. Men also report swollen testes, and that could be indicative of inflammation as well. Preliminary data show women who get the jab within the first 20 weeks of pregnancy have a miscarriage rate of 82% to 91%.5 There are also VAERS reports describing fetal damage. Of course, it could also impair future fertility.

As described earlier, some antibodies produced by the jab can react to human proteins. One protein that is similar to the spike protein that the antibodies attack is syncytin, which is essential for the fertilization of the egg. The concern is that the antibodies might attack and destroy syncytin, thereby disrupting and preventing implantation in the placenta.

Omicron — A Blessing in Disguise?

The jabs also perpetuate COVID, with ever-new variants of the virus.

Omicron looks like it's a milder virus, but incredibly infectious. It'll flash through the population and give everybody, essentially, a vaccine. It's kind of like a natural vaccine, I think.

I think Omicron is God's gift from heaven."

That blessing may be canceled out in those who have received multiple COVID jabs, however. Each dose erodes your immune response, such that it becomes increasingly compromised with each jab. Again, this has to do with the suppression of type-1 interferon, discussed earlier.

What Catalyzes Damage in Athletes?

More than 400 cases of serious heart problems and death have also been reported among professional athletes,6 who are some of the healthiest people on the planet. What mechanism can account for this phenomenon? How is it that the COVID jabs can cause enough damage to take out young people with optimized biology?

Seneff suspects that being fit might cause you to have more ACE2 receptors in the heart, and the S1 portion of the SARS-CoV-2 spike protein binds to the ACE2 receptor. She believes the spike protein is being delivered to the heart via exosomes, by way of the vagus nerve, and, again, the miR-155 exosome is associated with heart problems.7

Additionally, when the S1 spike protein binds to the ACE2 receptor,8 it disables the receptor. When you disable ACE2, you get an increase in ACE, which causes high blood pressure and elevates angiotensin 2. When angiotensin 2 is overexpressed, you can get intense inflammation in the heart. If you're engaging in intense exertion and your heart is inflamed, you can trigger cardiac arrest, which is what we see in many of these athlete cases. They're collapsing on the field.


Another focus of Seneff's and McCullough's paper is something called G4 or G-quadruplexes.

It turns out that prion proteins ... [are] made from RNA, and the RNA has these G4s. The protein can bind to the G4s in the RNA and both of them react. The theory is that the protein becomes prion-like. These prion proteins have two ways to be, one is safe and one is not safe, and the G4s increase the risk for prion protein misfolding.9
What is that going to do to the rest of the G4 regulatory process? We do not know. Nobody knows. Nobody has a clue."


To summarize the central point of Seneff's latest paper, the COVID jab causes alpha interferon suppression, which weakens your immune system. Indeed, regulators in the European Union are now warning that repeat COVID shots can weaken overall immunity.10

The primary mechanism is the impairment of alpha interferon response, which is essential for the proper activation of your innate immune system, your cellular immunity, mostly your T-cells and killer cells. When functioning properly, the cell launches the type-1 interferon response as soon as it's infected with a virus.

It triggers the immune cells to come in, kill the virus and remove the debris. This activates the humoral component of your immune system, the antibody production, which takes longer. (That's why they say you are not protected until 14 days after the injection.)

How is type-1 interferon suppressed by the jab? It's suppressed because type-1 interferon responds to viral RNA, and viral RNA is not present in the COVID shot. The RNA is modified to look like human RNA molecule, so the interferon pathway is not triggered. Worse, the interferon pathway is actively suppressed by the large number of spike proteins produced from the mRNA in the shot, and by the microRNAs in the exosomes released by the stressed immune cells.

Watch Dr. Seneff's interview here.

Sources and References:

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Omar Zaid

Author, Editor, Physician & Essential Monotheist